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Neocortex development

Overview of neurogenesis stages during mammalian neocortex development. (A) NSC self-renewal, (B) NSC differentiation, and (C) Neuron migration, specification, and neural circuit formation.Cells represented: neuroepithelial cells (NEC), apical radial glial cells (aRGC), basal radial glial cells (bRGC), intermediate progenitor cells (IPC), and neurons (newborn, migrating, differentiating, and mature). Ventricular and Subventricular zones are the proliferative zones, where the progenitors reside. Intermediate zone is the zone of neuron migration. Neocortex is the mammalian cerebral cortex highly organized into six horizontal layers (not all represented), where earlier born neurons occupy lower layers (deep layers), while later-born neurons occupy superficial layers (upper layers). Progenitor cells are maintained all over neocortex development to guarantee a reservoir for neurogenesis and gliogenesis.

Figuras que compõe a revisão: Translational Control during Mammalian Neocortex Development and Postembryonic Neuronal Function

Copyright: © 2020 Oliveira NCM, Lins ÉM, Massirer KB, Bengtson MH.

Seminars in Cell & Developmental Biology

DOI: 10.1016/j.semcdb.2020.09.006

Foram elaboradas no Adobe Illustrator.

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